Ellen Pompeo (Meredith Grey)

  Patrick Dempsey (Derek Shepherd)

  Katherine Heigl (Izzie Stevens)

  Justin Chambers (Alex Karev)

  Sandra Oh (Christina Yang)

  Isaiah Washington (Preston Burke)

  Kate Walsh (Addison M Shepherd)

  Eric Dane (Mark Sloan)

  Chandra Wilson (Miranda Bailey)

  James Pickens (Richard Webber)

  Sara Ramirez (Calie Torres)

  T.R Knight (George O'Malley)